At the same time, soil moisture affects the dissolution and transfer of nutrients in the soil, the absorption of nutrients by vegetation, and the activities of soil microorganisms, which also play an important role in the growth of vegetation. Soil water is the direct source of water consumption of vegetation, which directly affects the physiological activities of vegetation. Soil water is one of the important indicators that reflects climate change, and also has a direct relationship with precipitation. CRDI can reflect the time-lag effect between vegetation and VSWC in Guangdong, indicating it is a sensitive and applicable index for characterizing the time-lag phenomena of vegetation to soil moisture. Under the same conditions, the higher the soil humidity is, the longer the lag time is, and the longer the delay time is with the greater longitude. Both longitude and soil moisture affect the lag time of vegetation. However, when VSWC is relatively insufficient, grass shows the fastest response to the change of volumetric soil water content. When VSWC is sufficient, there is no obvious difference in time-lag between different types of vegetation. The results indicate that the response of vegetation to volumetric soil water content in Guangdong lagged 3.33 periods (9–35 days) on average. Taking the peak and valley positions of CRDI and VSWC as characteristic points, the lag time of vegetation to volumetric soil water content was obtained by judging the difference between the peak and valley positions of the two indexes. The response of vegetation to soil moisture in Guangdong Province from mid-October 2015 to the end of March 2017 was studied by using cloudy region drought index (CRDI) as the drought index and volumetric soil water content (VSWC) as the soil moisture index to measure the level of water stress on vegetation. It is of great significance to study the response of vegetation to soil moisture change, which is helpful for understanding the vulnerability of vegetation for regional and environmental protections. The content of soil water affects the physiological activities of vegetation, and the type of vegetation also affects the soil water balance.